We assume a dipolar approach which makes the problem non-linear. From the dynamic probabilistic model of the problem, we formulate the Extended Kalman Filter and Particle Filter solutions. In order to test the algorithms, we designed an experimental protocol based on error-related potentials. During the experiments, our dynamic solutions have allowed the estimation of sources which are varying in position and moment within the brain volume.
Results confirm the activation of the anterior cingulate cortex which is the brain structure associated with error processing. These findings demonstrate the good performance of the dynamic solutions for estimating and tracking EEG neural generators. Keywords: Deformable image registration , X-ray imaging applications breast, lung, abdominal, dental, thoracic, etc. Abstract: In this paper, we propose an automated method for colon registration from supine and prone scans.
Four anatomical salient points on the colon are distinguished first. Then correlation optimized warping COW method is applied to the segments defined by the anatomical landmarks to find better global registration based on local correlation of segments. To utilize more features along the colon centerline, we extended the COW method by embedding canonical correlation analysis into it for correlation calculation of colon segments.
To verify the effectiveness of the proposed method, we tested the algorithm on a CTC dataset of 19 patients with 23 polyps. Experimental results show that by using our method, the estimation error of polyp location could be reduced Keywords: Deformable image registration , MR Neuroimaging , Optical imaging Abstract: The architectonic analysis of the human cerebral cortex is presently based on the examination of stained tissue sections. Recent progress in high-resolution magnetic resonance imaging MRI promotes the feasibility of an in vivo architectonic analysis. Since the exact relationship between the laminar fine-structure of a cortical MRI signal and histological cyto- and myeloarchitectonic staining patterns is not known, a quantitative study comparing high-resolution MRI to histological ground truth images is necessary for validating a future MRI based architectonic analysis.
This communication describes an ongoing study comparing post mortem MR images to a myelin-stained histology of the brain cortex. After establishing a close spatial correspondence between histological sections and MRI using a slice-to-volume nonrigid registration algorithm, transcortical intensity profiles, extracted from both imaging modalities along curved trajectories of a Laplacian vector field, are compared via a cross-correlational analysis.
Keywords: Rigid-body image registration , X-ray radiography , X-ray imaging applications breast, lung, abdominal, dental, thoracic, etc.
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- CINCUENTA SECRETOS DE GREY 3 (Spanish Edition).
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- Suppression of Somatosensory Evoked Cortical Responses by Noxious Stimuli.
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Abstract: In this paper, we introduce a 2d-3d registration method for searching the motion of knee bones. We use a low dose bi-planar acquisition system that provides us with simultaneous frontal and profile radiographs in different positions, and the 3d volume reconstruction of the standing position. The purpose here is to reduce the user intervention during the motion tracking.
The registration method is based on the central slice Fourier Transform theorem. Motion results with rotations and translations using synthetic data are shown. Keywords: Deformable image registration , X-ray CT , Multimodal image fusion Abstract: The aim of this study is to provide a method to track the anatomical alterations of parotid glands during radiation treatment.
The method we implemented is based on an intensity-based free-form deformable registration to realign the planning kilo-Voltage CT kVCT and the daily Mega-Voltage MVCT image sets and on an automatic contour propagation algorithm based on surface construction by triangular mesh. The accuracy of the method was evaluated through visual inspection and comparison with manual contours drawn by expert physicians. The uncertainties of automatic contours were similar to those of manual contours, in terms of parotid volumes and center-of-mass distances.
The parotid volumes decreased with a median total loss of We observed an average medial shift of parotid center-of-mass of 3. The deformable registration method presented in this work provides an accurate tool for the automatic evaluation of parotid changes occurring during a radiotherapy treatment period. Keywords: Deformable image registration , Rigid-body image registration Abstract: Image registration is a crucial step for many image-assisted clinical applications such as surgery planning and treatment evaluation.
In this paper we proposed a landmark based nonlinear image registration algorithm for matching 2D image pairs. The algorithm was shown to be effective and robust under conditions of large deformations. In landmark based registration, the most important step is establishing the correspondence among the selected landmark points. This usually requires an extensive search which is often computationally expensive. We introduced a nonregular data partition algorithm using the K-means clustering algorithm to group the landmarks based on the number of available processing cores.
The step optimizes the memory usage and data transfer. Keywords: Rigid-body image registration Abstract: Retinal image registration is essential and crucial for ophthalmologists to diagnose various diseases. A great number of methods have been developed to solve this problem, however, fast and accurate retinal image registration is still a challenging problem since the great content complexity and low image quality of the unhealthy retina. This paper provides a new retinal image registration method based on salient feature regions SFR.
We first extract the SFR in each image based on a well defined region saliency metric. Next, SFR are matched by using an innovative local feature descriptor. Then we register those matched SFR using local rigid transformation. Finally, we register the two images adopting global second order polynomial transformation with locally rigid registered region centers as control points. Experimental results prove that our method is very fast and accurate, especially quite effective for the low quality retinal images registration. Keywords: Acoustic, mechanical, and thermal sensors and systems , Optical and photonic sensors and systems Abstract: Detection of circulating tumor cells CTC's in human blood and lymph systems has the potential to aid clinical decision making in the treatment of cancer.
Anesthesia Analgesia September 2009
The presence of CTC's may signify the onset of metastasis, indicate relapse, or may be used to monitor disease progression. A photoacoustic flowmetry system was designed and tested for detecting circulating melanoma cells CMC's by exploiting the broadband absorption spectrum of melanin within CMC's.
The device was tested on cultured melanoma cells in saline suspension and in a Stage IV melanoma patient. The device showed a detection threshold of a single melanotic melanoma cell from culture. Transient photoacoustic events were detected in a sample derived from a Stage IV melanoma patient that corresponded to particles passing through the laser beam path, indicating the presence of single melanoma cells in the human circulatory system.
Keywords: Optical and photonic sensors and systems Abstract: The polarization mismatch of the sample and reference arms in optical fiber based low coherence interferometry has critical effect on its depth resolution when the light source is partially polarized: When the polarization states of the two arms are matched the measured point spread function PSF is almost identical to the theoretical prediction; When their polarization states are mismatched the PSF can be so distorted that the depth resolution is degraded to several times of the theoretical value.
When the source light is polarized the depth resolution becomes independent of the polarization mismatch.
Nihon-chan sil vous plait / Event in September 2009
Keywords: Optical and photonic sensors and systems , Smart biological and chemical sensor materials Abstract: Recent advances in optical imaging have resulted in a plethora of optical probes geared towards in vivo imaging. Optical probes that emit in the near-infrared region are most aptly suited for in vivo applications due to depth of tissue penetration and minimal absorption by water and naturally occurring fluorophores. Fluorescence lifetime contrast is complementary to fluorescence intensity and requires probes which have fluorescent lifetime sensitivity to environmental parameters.
The engineering of such probes for certain applications in live animals such as measuring the degradation of nanocarriers and monitoring renal functions is presented and the mechanism of action is discussed. Keywords: Optical and photonic sensors and systems Abstract: We present the method and application of optical reflectance spectroscopy to differentiate prostate cancer from normal tissue using a needle like, bifurcated, fiber-optic probe. An analytical expression to model light reflectance recently published by Zonios et.
A total of 23 cases of human prostate specimens were investigated to analyze statistical differences between the respective cancerous tissues versus normal tissues. The results demonstrate that the derived hemodynamic parameters and optical properties can serve as good bio-markers to differentiate tumor tissue from normal tissue in human prostate.
Keywords: Optical and photonic sensors and systems , Implantable systems Abstract: Dermally-implanted microparticle sensors are being developed for on-demand monitoring of blood sugar levels. For these to be deployed in vivo, a matched opto-electronic system for delivery of excitation, collection and analysis of escaping fluorescent signal is needed.
Previous studies predicted the characteristics of fluorescence from microparticle sensors to facilitate design of hardware system. Based on the results of simulations, we designed and constructed the optical part of this opto-electronic system. This study experimentally verified the simulation results and tested the capability of the designed optical system. Reliable skin phantoms sufficient for future dynamic tests were developed.
Skin phantoms with different thicknesses were made and the optical properties of skin phantoms were determined with an integrating sphere system and Inverse Adding-Doubling method. Measurements of sensor emission spectrum through phantoms with different thicknesses were done with the designed optical system. Simulations for the experiment situation were performed. The experimental measurements agreed well with simulations in most cases. The results of hardware experiment and validation with skin phantoms provided us with critical information for future animal experiments.
Keywords: Optical and photonic sensors and systems , Biological and chemical sensors Abstract: A novel optical non-invasive in vivo blood glucose concentration BGL measurement technique, named "Pulse Glucometry", was combined with a kernel method; support vector machines. Secondly, SVM method was applied to make a nonlinear discriminant calibration model for "Pulse glucometry.
Keywords: Major advance in bio- micro- and nano- technology and applications , Major advance in medical devices Abstract: High-intensity focused ultrasound HIFU is being promoted as a noninvasive method to treat certain primary solid tumors, metastatic disease, and enhance drug delivery. The field of medicine is evolving towards increasing use of noninvasive and minimally invasive therapies such as HIFU.
This article provides an overview of current clinical applications of HIFU and future requirements to expand the clinical applications of this technique. Keywords: Major advance in functional, molecular, cellular imaging , Major advance in bio- micro- and nano- technology and applications Abstract: When microbubble contrast agents are driven by ultrasound, the transport of drugs and particles across cell membranes and blood vessel walls is enhanced. While a wide range of acoustic parameters enhance delivery, the acoustic parameters that maximize delivery while simultaneously minimizing biological effects have not been fully characterized.
Using parameters relevant to diagnostic imaging and drug delivery, we observe fluid jets that impinge on the surface and tunnels that follow the sound beam axis.
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Keywords: Major advance in functional, molecular, cellular imaging , Major advance in medical devices Abstract: We present experimental results illustrating the unique advantages of dual-mode array DMUA systems in monitoring and guidance of high intensity focused ultrasound HIFU lesion formation. DMUAs offer a unique paradigm in image-guided surgery; one in which images obtained using the same therapeutic transducer provide feedback for: 1 refocusing the array in the presence of strongly scattering objects, e.
These forms of feedback have been demonstrated in vitro in preparation for the design and implementation of a real-time system for imaging and therapy with DMUAs. The results clearly demonstrate that DMUA image feedback is spatially accurate and provide sufficient spatial and contrast resolution for identification of high contrast objects like the ribs and significant blood vessels in the path of the HIFU beam.
Keywords: Major advance in functional, molecular, cellular imaging , Major advance in medical devices Abstract: MR guidance of high intensity focused ultrasound is evolving with each new application. In this paper we describe ongoing research in the MR-guidance aspect of MR-guided focused ultrasound. Keywords: Major advance in medical devices , Major advance in bio- micro- and nano- technology and applications Abstract: In the U.
The Act defines several regulatory paths to market depending on the complexity of the device and indications for use. For most high intensity focused ultrasound HIFU devices the premarket submissions include both pre-clinical and clinical data. Pre-clinical testing generally comprises ultrasound power measurements and field characterization, in vitro and in vivo temperature measurements, thermal computational modeling, and demonstrating the accuracy for targeting the region of interest and monitoring treatment progress.
Protocols for clinical trials are developed by the device sponsor in conjunction with FDA medical and scientific staff. Currently there are no recognized guidance or standards documents for HIFU testing that could be used in the regulatory review process, but such work is underway within the International Electrotechnical Commission. Keywords: Career development , Innovation , Intellectual property Abstract: With concerns of the current health care system, biomedical engineers have expertise, opportunity and responsibility in developing innovations that may improve cost, coverage and quality of health care delivery.
This paper reviews the product development process in the medical device industry, and the associated training and experience required for biomedical engineers involved at each stage of the process.
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